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Fiche Santé détaillée


Toxicologie de la matière active : thiabendazole

La fiche Santé détaillée a été élaborée selon la méthodologie développée dans l'indicateur de risque des pesticides du Québec (IRPeQ).


Fiche Santé détaillée

thiabendazole

Abréviation : TZL
Types de pesticides : Fongicide
Numéro CAS : 148-79-8

Toxicité aiguë

4735 US EPA: US Environmental Protection Agency, 2001. Thiabendazole (060101) and Thiabendazole salt (060102): A Revised HED Risk Assessment for the Reregistration Eligibility Decision (RED) Document. Case No. 2670. Barcode D275829. Office of Prevention, Pesticides and Toxic Substances, June 21, 2001, 41 p.
> 2000 US EPA: US Environmental Protection Agency, 2001. Thiabendazole (060101) and Thiabendazole salt (060102): A Revised HED Risk Assessment for the Reregistration Eligibility Decision (RED) Document. Case No. 2670. Barcode D275829. Office of Prevention, Pesticides and Toxic Substances, June 21, 2001, 41 p.
> 0.5 Tomlin, C.D.S. (dir.), 2003. The Pesticide Manual, a World Compendium, 13th edition., The British Crop Protection Council, Alton, Hampshire, UK, 1344 p.
Très peu ou pas irritant US EPA: US Environmental Protection Agency, 2001. Thiabendazole (060101) and Thiabendazole salt (060102): A Revised HED Risk Assessment for the Reregistration Eligibility Decision (RED) Document. Case No. 2670. Barcode D275829. Office of Prevention, Pesticides and Toxic Substances, June 21, 2001, 41 p.
Très peu ou pas irritant US EPA: US Environmental Protection Agency, 2001. Thiabendazole (060101) and Thiabendazole salt (060102): A Revised HED Risk Assessment for the Reregistration Eligibility Decision (RED) Document. Case No. 2670. Barcode D275829. Office of Prevention, Pesticides and Toxic Substances, June 21, 2001, 41 p.
Non US EPA: US Environmental Protection Agency, 2001. Thiabendazole (060101) and Thiabendazole salt (060102): A Revised HED Risk Assessment for the Reregistration Eligibility Decision (RED) Document. Case No. 2670. Barcode D275829. Office of Prevention, Pesticides and Toxic Substances, June 21, 2001, 41 p.
Non
III
III


0,1 pour les femmes de 13 à 50 ans et pour les autres sous groupes de la populations US EPA: US Environmental Protection Agency, 2002. Reregistration Eligibility Decision (RED) Thiabendazole. Office of Prevention, Pesticides and Toxic Substances, Document EPA 738-R-02-XXX, October 2002, 103 p. http://www.epa.gov/pesticides/reregistration/REDs/thiabendazole_red.pdf

US EPA: US Environmental Protection Agency, 2001. Thiabendazole (060101) and Thiabendazole salt (060102): A Revised HED Risk Assessment for the Reregistration Eligibility Decision (RED) Document. Case No. 2670. Barcode D275829. Office of Prevention, Pesticides and Toxic Substances, June 21, 2001, 41 p.

0,3 pour les femmes en âge de procréer et 1,0 pour les autres sous groupes de la population FAO: Food and Agriculture Organization of the United Nations, 2006. Pesticide residues in food – 2006. Report of the Joint Meeting of the FAO Panel of Experts on Pesticide Residues in Food and the Environment and the WHO Core Assessment Group on Pesticide Residues Rome, Italy, 3–12 October 2006. FAO Plant Production and Protection Paper 187, 400 p.
Bilan de la toxicité aiguë
Le thiabendazole possède une faible toxicité aiguë chez les animaux de laboratoire. Il est peu ou pas irritant et il n'est pas un sensibilisant cutanée.
US EPA: US Environmental Protection Agency, 2002. Reregistration Eligibility Decision (RED) Thiabendazole. Office of Prevention, Pesticides and Toxic Substances, Document EPA 738-R-02-XXX, October 2002, 103 p. 
http://www.epa.gov/pesticides/reregistration/REDs/thiabendazole_red.pdf
US EPA: US Environmental Protection Agency, 2001. Thiabendazole (060101) and Thiabendazole salt (060102): A Revised HED Risk Assessment for the Reregistration Eligibility Decision (RED) Document. Case No. 2670. Barcode D275829. Office of Prevention, Pesticides and Toxic Substances, June 21, 2001, 41 p.

Tomlin, C.D.S. (dir.), 2003. The Pesticide Manual, a World Compendium, 13th edition., The British Crop Protection Council, Alton, Hampshire, UK, 1344 p.

Toxicité chronique

Cancérigène possible chez l'humain US EPA: US Environmental Protection Agency, 2006. Chemicals evaluated for carcinogenic potential by the Office of Pestice Programs. Science Information Management branch, Health Effects Division, Office of Pesticides programs, April 26, 2006, 49 p. 
http://envirocancer.cornell.edu/turf/chemseval.pdf
Non génotoxique chez l'humain US EPA: US Environmental Protection Agency, 2001. Thiabendazole (060101) and Thiabendazole salt (060102): A Revised HED Risk Assessment for the Reregistration Eligibility Decision (RED) Document. Case No. 2670. Barcode D275829. Office of Prevention, Pesticides and Toxic Substances, June 21, 2001, 41 p. 

EC: European Commission, 2001. Review report for the active substance thiabendazole. Directorate-General Health & Consumer Protection, Directorate E - Public, animal and plant health, Unit E1 Legislation relating to crop products and animal nutrition, 7603/VI/97-final, 22 March 2001, 41 p.
http://europa.eu.int/comm/food/plant/protection/evaluation/existactive/list1-26_en.pdf
Le thiabendazole est non génotoxique in vivo mais il a causé une induction d'aneuploïdie in vitro à des concentrations élevées.
Perturbateur endocrinien potentiel US EPA: US Environmental Protection Agency, 1999. Thiabendazole; P.C.Code 060101. The HED toxicology chapter for the Reregistration Eligibility Decision document (RED). DP Barcode: D251076, Submission: S551722. Office of Prevention, Pesticides and Toxic Substances, October 12, 1999, 23 p.

EC: European Commission, 2001. Review report for the active substance thiabendazole. Directorate-General Health & Consumer Protection, Directorate E - Public, animal and plant health, Unit E1 Legislation relating to crop products and animal nutrition, 7603/VI/97-final, 22 March 2001, 41 p.
http://europa.eu.int/comm/food/plant/protection/evaluation/existactive/list1-26_en.pdf
Les études mécanistes indiquent que les effets observés chez les rats sur les hormones thyroïdiennes sont dus à l'induction d'enzymes hépatiques qui influenceraient la clairance de la thyroxine. Ce mécanisme serait spécifique aux rats. Cependant, l'EPA a classé le thiabendazole comme un cancérigène probable mais à des doses assez élevées pour causer une perturbation de la balance des hormones thyroïdiennes. Ce qui implique une perturbation possible de la fonction endocrinienne.
Aucun effet ou effets mineurs non préoccupants EC: European Commission, 2001. Review report for the active substance thiabendazole. Directorate-General Health & Consumer Protection, Directorate E - Public, animal and plant health, Unit E1 Legislation relating to crop products and animal nutrition, 7603/VI/97-final, 22 March 2001, 41 p.
http://europa.eu.int/comm/food/plant/protection/evaluation/existactive/list1-26_en.pdf
La reproduction est non affectée à des doses toxiques parentales.
Aucun effet ou effets mineurs non préoccupants EC: European Commission, 2001. Review report for the active substance thiabendazole. Directorate-General Health & Consumer Protection, Directorate E - Public, animal and plant health, Unit E1 Legislation relating to crop products and animal nutrition, 7603/VI/97-final, 22 March 2001, 41 p.
http://europa.eu.int/comm/food/plant/protection/evaluation/existactive/list1-26_en.pdf
Une fœtotoxicité a été observée à des doses toxiques maternelles seulement.
0,1 US EPA: US Environmental Protection Agency, 2001. Thiabendazole (060101) and Thiabendazole salt (060102): A Revised HED Risk Assessment for the Reregistration Eligibility Decision (RED) Document. Case No. 2670. Barcode D275829. Office of Prevention, Pesticides and Toxic Substances, June 21, 2001, 41 p.
0,1 IPCS: International Programme on Chemical Safety, 2002. Inventory of IPCS and other WHO pesticide evaluations and summary of toxicological evaluations performed by the Joint Meeting on Pesticide Residues (JMPR): Evaluations through 2002. OMS, Genève, WHO/PCS/02.3.
http://www.inchem.org/documents/jmpr/jmpeval/jmpr2002.htm
Il n'y a aucune évidence de neurotoxicité dans les études à court et à long terme US EPA: US Environmental Protection Agency, 1999. Thiabendazole; P.C.Code 060101. The HED toxicology chapter for the Reregistration Eligibility Decision document (RED). DP Barcode: D251076, Submission: S551722. Office of Prevention, Pesticides and Toxic Substances, October 12, 1999, 23 p.
Bilan des effets à long terme
Lors d'études chez les animaux de laboratoire, le foie et la thyroïde étaient les principaux organes cibles du thiabendazole. On a observé chez les rats, une réduction de gain de poids corporel et une hypertrophie du foie ainsi que des adénomes et une hyperplasie des cellules folliculaires de la thyroïde. Le produit serait un cancérigène probable mais à des doses assez élevées pour causer une perturbation de la balance des hormones thyroïdiennes. l'EPA le juge probablement non cancérigène à des doses non assez élevées pour causer une perturbation de la balance des hormones thyroïdiennes. Le thiabendazole était non toxique pour la reproduction et le développement dans les études animales. Il n'est ni neurotoxique, ni génotoxique.
US EPA: US Environmental Protection Agency, 1999. Thiabendazole; P.C.Code 060101. The HED toxicology chapter for the Reregistration Eligibility Decision document (RED). DP Barcode: D251076, Submission: S551722. Office of Prevention, Pesticides and Toxic Substances, October 12, 1999, 23 p. 

EC: European Commission, 2001. Review report for the active substance thiabendazole. Directorate-General Health & Consumer Protection, Directorate E - Public, animal and plant health, Unit E1 Legislation relating to crop products and animal nutrition, 7603/VI/97-final, 22 March 2001, 41 p.
http://europa.eu.int/comm/food/plant/protection/evaluation/existactive/list1-26_en.pdf

US EPA: US Environmental Protection Agency, 2002. Reregistration Eligibility Decision (RED) Thiabendazole. Office of Prevention, Pesticides and Toxic Substances, Document EPA 738-R-02-XXX, October 2002, 103 p. 
http://www.epa.gov/pesticides/reregistration/REDs/thiabendazole_red.pdf
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